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Abstract #3206

Quantitative characterization of disease progression in a mouse model of non-alcoholic steatohepatitis using molecular MR and non-contrast MR imaging

Philip Alan Waghorn1, Diego Ferreira1, Chloe Jones1, Nicholas Rotile1, Iris Chen1, Chuantao Tu1, Bryan Fuchs2, and Peter Caravan1

1A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Division of Surgery, Massachusetts General Hospital, Boston, MA, United States

To deliver a non-invasive quantitative measure of patients with nonalcoholic fatty liver disease (NAFLD) who are likely to develop a fibrotic pathology, we characterized the natural history of a nonalcoholic steatohepatitis (NASH) mouse model using MRI. Characterization included fat quantification and MR relaxometry measurements by imaging at 4 time points and comparing with histology and biochemical markers. Fibrogenesis was assessed using the novel Gd-based MR probe, Gd-Hyd which was previously shown to detect fibrogenesis in a mouse CCl4 model of liver fibrosis

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