Dynamic Contrast-Enhanced (DCE) imaging is widely used in detection and characterization of many liver diseases. In clinical practice, breath holding is commonly used to overcome respiratory motion and get high quality images. However, long breath holds can be painful or unavailable for some patients. To address this problem, we present a variable density 2D CAIPIRINHA sampling technique with a novel reconstruction framework for highly accelerated volumetric DCE liver imaging. Simulation and in-vivo experiments were performed to evaluate the performance of the proposed method compared with other current techniques. The results show great improvement of image quality within shorter acquisition time.