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Abstract #3225

Comparison of Doppler Echocardiography Mean Transvalvular Aortic Pressure Gradient to 4D Flow MRI

Michael James Rose1, Kelly Jarvis2,3, Susanne Schnell2, James D Thomas4, Joshua D Robinson1,5,6, Cynthia K Rigsby1,2, Michael Markl2,3, and Alex J Barker2

1Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 2Department of Radiology, Feinberg School of Medicine, Northwestern University, 3Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, 4Division of Cardiology, Feinberg School of Medicine, Northwestern University, 5Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States, 6Department of Pediatrics, Feinberg School of Medicine, Northwestern University

Mean and peak pressure gradients are an important measure of aortic stenosis severity. In this study, we present a novel method for measuring mean pressure gradients using 4D flow MRI. 4D flow MRI peak and mean pressure gradients were measured in 23 pediatric BAV patients and compared to Doppler echocardiography (echo). There was no significant difference between 4D flow MRI and echo in peak or mean pressure gradients. 4D flow MRI mean pressure gradients correlated better with echo than peak pressure gradients (R2= 0.78 vs. R2=0.27), suggesting 4D flow to be better suited for measuring mean pressure gradients.

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