Acute pulmonary hypertension was induced in dogs by micro embolization. RHC was performed, as well as 4D flow MRI pre and post-embolization. MRI data was used to develop a CFD model of the proximal pulmonary circulation while comparing two inlet boundary conditions: velocity definition as defined from 2D flow MRI and from 4D flow MRI, which takes into account the directionality of the velocity. WSS tended to decrease post-embolization. Pressure gradient distribution shows that during peak systole, a constant normal inlet condition might be sufficient for CFD simulation; however, differences might be present during diastole.