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Abstract #3249

Quantitative MRI measurement of the interplay between myocardial function, perfusion, structure and metabolism during acute and chronic remodeling in a porcine model of myocardial infarction

Smita Sampath1, Sarayu Annamalai Parimal2, Wei Huang3, Ibrahim Mazlan4,5, Grace Croft4,5, Teresa Totman4,5, Yvonne Wei Zheng Tay6, Elaine Manigbas6, Miko May Lee Chang7, Anqi Qiu7, Michael Klimas8, Jeffrey L Evelhoch8, Dominique PV de Kleijn4,5, and Chih-Liang Chin1

1Translational Biomarkers, Merck Sharp & Dohme, Singapore, Singapore, 2Translational Biomarkers, Merck Sharp & Dohme, Singapore, 3Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States, 4Cardiovascular Research Institute, National University Heart Center, Singapore, 5Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 6Comparative Medicine Imaging Facility, Center for Life Sciences, National University of Singapore, Singapore, 7Department of Biomedical Engineering, National University of Singapore, Singapore, 8Translational Biomarkers, Merck & Co., Inc., West Point, PA, United States

We present a comprehensive characterization of LV structure, function, perfusion and metabolism in a porcine animal model with myocardial infarction with view to develop a translational platform for future testing of safety and efficacy of novel heart failure therapeutics. Dynamic contrast enhanced MRI and tagging MRI are employed to obtain non-invasive quantitative magnetic resonance imaging (MRI) biomarkers for characterization. Results demonstrate an acute decrease in function and perfusion in the infarct region and functional compensation in the remote region with associated increased metabolic activity. Chronic remodeling is associated with decreased metabolic activity in the infarct region along with increased fibrosis.

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