We present a comprehensive characterization of LV structure,
function, perfusion and metabolism in a porcine animal model with myocardial
infarction with view to develop a translational platform for future testing of
safety and efficacy of novel heart failure therapeutics. Dynamic contrast enhanced MRI and tagging MRI
are employed to obtain non-invasive quantitative magnetic resonance imaging
(MRI) biomarkers for characterization.
Results demonstrate an acute decrease in function and perfusion in the infarct
region and functional compensation in the remote region with associated
increased metabolic activity. Chronic
remodeling is associated with decreased metabolic activity in the infarct
region along with increased fibrosis.