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Abstract #3270

Dynamic PET/MR Imaging of Glucose Utilization and Contractile Function Under Hypoxic Stress

Gregory Barton1, Kara Goss2, Niti Aggarwal3, Marlowe Eldridge1, and Alan McMillan4

1Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, 3Departments of Medicine & Radiology, University of Wisconsin-Madison, Madison, WI, United States, 4Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States

The purpose of this study was to establish a methodology that could be used to study the dynamic relationship between cardiac contractile function and metabolism in a serial rest-stress model using dynamic cardiac PET/MR. To assess dynamic changes in cardiac glucose metabolism we evaluated the use of a continuous infusion of 18F-FDG. We found that increases in cardiac contractility were coupled with an increase in glucose utilization in the myocardium under hypoxic stress conditions. These results demonstrate the feasibility of performing simultaneous measures of contractile function and metabolism in the heart.

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