Chronic kidney disease (CKD) is a heterogeneous disease, with previous studies showing conflicting changes in MR parameters. Here, we use multi-parametric MRI of DWI, T1 and T2* mapping and ASL to assess haemodynamic and structural changes in Stage 3 and 4 CKD patients and examine the reproducibility of these measures. A significant reduction in renal cortex ADC and perfusion was found between CKD patients and healthy volunteers. In contrast, renal cortex and medulla T1 values increased in CKD, with a reduction in corticomedullary differentiation. MR measures in CKD patients were found to be highly reproducible between scan sessions.