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Abstract #3298

The Cortico-Medullary ADC Difference reduces inter-system variability in Renal Diffusion-Weighted Imaging

Iris Friedli1, Lindsey A Crowe1, Bénédicte MA Delattre2, Thomas De Perrot2, Pierre-Yves Martin2, Sophie De Seigneux2, and Jean-Paul Vallée2

1Radiology, University of Geneva, Geneva, Switzerland, 2Geneva University Hospitals

Our goal was to determine if the cortico-medullary Apparent Diffusion Coefficient difference (ΔADC), that previously exhibited a strong correlation with renal fibrosis, is independent of MR system. Comparison of ADC (cortex, medulla and Δ) over Siemens (1.5T AERA, 3T PRISMA, 3T SKYRA) and Philips (1.5T INGENIA, 3T PET-MR) systems was carried out in eight volunteers. Significant ADC differences were measured for the cortex and medulla independently using PRISMA and AERA and, for cortex of AERA and INGENIA (p<0.05). ΔADC corrected inter-scanner variability with no significant differences across all MR systems (p>0.05).

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