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Abstract #3311

Repeatability of regional lung ventilation quantification using 19F fluorinated gas washout magnetic resonance imaging in free breathing

Marcel Gutberlet1,2, Andreas Voskrebenzev1,2, Agilo Kern1,2, Till Kaireit1,2, Jens Hohlfeld2,3, Frank Wacker1,2, and Jens Vogel-Claussen1,2

1Institute of Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany, 3Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Since quantification of regional lung ventilation using 19F fluorinated gas washout imaging in free breathing is feasible even in obstructed lungs, it may improve diagnosis, monitoring and therapy of obstructive lung diseases like asthma and COPD. However, for application in clinical studies the knowledge of the accuracy of this technique is important. Repeatability of the 19F gas washout parameters washout time, number of breaths and fractional ventilation between to scans was assessed in eight healthy volunteers. Due to the excellent repeatability of the number of breaths and fractional ventilation, regional lung ventilation can be accurately quantified using 19F gas washout MRI in free breathing.

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