Purpose of the study was to assess the feasibility of SENCEFUL ventilation imaging for evaluation of therapy success after endoscopic lung volume reduction. Two patients with lung emphysema who underwent bronchial valve implantation were scanned before and after the procedure using SENCEFUL-MRI. Color-coded lung ventilation maps and quantitative ventilation values were pre- and postinterventionally compared. The first patient showed a ventilation defect corresponding to the location of the implanted valves with reduction of the quantitative ventilation. The second patient did not present such alterations and was later classified as non-responder to therapy. SENCEFUL-MRI detected clinically successful and non-successful outcomes correctly.