To propose a novel flip angle scheme for hyperpolarized gas multi-b diffusion MRI. It combined the variable and constant flip angles and was named as the combination of variable and constant flip angle (CVCFA). Computer simulation was used to systematically compare the proposed flip angle scheme with the common-used flip angle schemes, including the interleaved constant flip angle (ICFA) and the variable flip angle (VFA) schemes. The CVCFA scheme was used for hyperpolarized xenon diffusion MRI to measure the pulmonary morphology in rats, noninvasively. The results showed the CVCFA was suited for the hyperpolarized gas multi-b diffusion MRI.