Diffusion images obtained with spin echo – echo planar imaging (SE-EPI) can be acquired quickly and efficiently. In prostate applications areas of susceptibility can cause image distortion. The purpose of this work is to address these distortions with the use of multi-shot EPI techniques. A previously defined term, pseudo-gradient, is shown to be a useful analytical tool to explain and guide in the choice of acquisition parameters. Phantom and in-vivo results show the benefits of multi-shot scans to reduce distortions.