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Abstract #3359

Comparing the value of MRI ultra-high-b-value DWI and standard DWI in grading cerebral astrocytomas and their association with aquaporin-4

Yan Tan1, Hui Zhang1, Xiaochun Wang1, and Dandan Zheng2

1The First Hospital of Shanxi Medical University, TaiYuan, People's Republic of China, 2GE Healthcare MR Research China, People's Republic of China

Ultral-High-b-value DWI (UHBV-DWI) was shown to improve the diagnostic performance of DWI in grading gliomas. We compare the value of MRI UHBV-DWI and conventional DWI for grading astrocytomas, and to analyze the correlation of respective parameters with aquaporin (AQP) expression. We found UHBV-ADC (0.810) showed a larger area under the curve (AUC) than that of ADC (0.713) (P < 0.05). The ADC value showed a negative correlation with AQP4 mRNA expression (r = -0.357; P = 0.024). UHBV-ADC value positively correlated with the AQP4 mRNA expression (r = 0.646; P < 0.01). So UHBV-DWI allowed for a more accurate grading of cerebral astrocytoma as compared to DWI. UHBV-ADC may be related with the AQP4 mRNA levels.

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