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Abstract #3365

Comprehensive analysis of the predictors of microvessel invasion in hepatocellular carcinoma: Diffusion kurtosis imaging (DKI) combined with radiological and clinical factors.

wentao wang1, LI Yang1, Xixing HU1, Robert Grimm2, caixia Fu3, XU Yan4, mengsu zeng1, and shengxiang rao1

1Radiology department, zhongshan Hospital, Shanghai, People's Republic of China, 2MR Application Developmen, Siemens Healthcare, Erlangen, Germany, 3Siemens Shenzhen Magnetic Resonance Ltd, shenzhen, People's Republic of China, 4MR Collaboration NE Asia, Siemens Healthcare, shanghai, People's Republic of China

Diffusion Kurtosis Imaging (DKI) maps, preoperative radiological features and clinical-pathologic findings were calculated to assess their diagnostic accuracy for microvascular invasion (MVI) of hepatocellular carcinoma (HCC) in patients who were undergoing curative liver resection. Multivariate regression analysis was performed to identify independent predictive factors for MVI. The study shows that Mean Kurtosis (MK), non-smooth margin, peritumoral enhancement and incomplete radiological capsule suggest a high probability of microvessel invasion of HCC. Multivariate analysis confirmed that MK and capsule integrity show statistical significance correlation with MVI. In conclusion, MK and capsule appearance might be the predictors for MVI of primary hepatocellular carcinoma.

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