Diffusion Kurtosis Imaging (DKI) maps, preoperative radiological features and clinical-pathologic findings were calculated to assess their diagnostic accuracy for microvascular invasion (MVI) of hepatocellular carcinoma (HCC) in patients who were undergoing curative liver resection. Multivariate regression analysis was performed to identify independent predictive factors for MVI. The study shows that Mean Kurtosis (MK), non-smooth margin, peritumoral enhancement and incomplete radiological capsule suggest a high probability of microvessel invasion of HCC. Multivariate analysis confirmed that MK and capsule integrity show statistical significance correlation with MVI. In conclusion, MK and capsule appearance might be the predictors for MVI of primary hepatocellular carcinoma.