Probing Microstructure of Brain Tumor: A NODDI Study
Shin Tai Chong1, Hung-Wen Kao2, Chien-Yuan Eddy Lin3,4, Chiao-Chi Chen5, Ching-Po Lin1, and Chen Chang5
1Institute of Neuroscience, National Yang-Ming University, Taipei city, Taiwan, 2Department of radiology, Tri-Service General Hospital, National Defense Medical Center, Taiwan, 3GE Healthcare, Taipei, Taiwan, 4GE Healthcare MR Research China, Beijing, People's Republic of China, 5Institute of Biomedical Sciences, Academia Sinica, Taiwan
We hypothesized that the model-based diffusion model, Neurite Orientation Dispersion and Density Imaging (NODDI), could help probing microstructures of brain tumos in different types and gradings. The model perfomed better than a conventional diffusion model in differetiating meningiomas and gliomas in different grades while the two models showed significant differences of the diffusion indices between meningiomas and gliomas. In the NODDI analysis, both VFic and VFec show great potential to probe the cellularity of brain tumors.
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