This study compared a fast SE-EPI-based T2 mapping method with a conventional CPMG-based method. The SE-EPI method is based on multi-TE data and can be integrated into a diffusion sequence with very fast acquisition speed (around 30 s). The voxel-by-voxel and region of interest (ROI)-based comparisons were performed using two methods, which showed that their T2 maps have a strong correlation. In addition, the clinical validation showed that the T2 maps of the two methods have similar statistical significance and can be used to differentiate between prostate cancer (PCa) and benign prostatic hyperplasia (BPH). This work suggests that the SE-EPI-based method is a quick quantification method, and could be used or combined with diffusion and other quantification methods for multi-parametric analysis. In addition, it may also have potential applications in body regions which are susceptible to motion artifacts.