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Abstract #3429

Determination of Droplet Size Distribution in Brown Adipose Tissues by Diffusion NMR Spectroscopy

Sanjay Kumar Verma1, Jadegoud Yaligar1, Navin Michael2, Tian Xianfeng1, Venkatesh Gopalan1, Suresh Anand Sadananthan2, Rengaraj Ananthraj1, and S. Sendhil Velan1,2

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2Singapore Institute for Clinical Sciences, Singapore

Non-Invasive Imaging of Brown Adipose Tissue is of significant interest due to its potential to combat obesity and diabetes. In this study, we have utilized diffusion spectroscopy to estimate the droplet size distribution in chow and high-fat diet fed brown adipose tissues obtained from rodents. The high-fat diet BAT exhibited reduction in the restriction due to the increase in droplet size. The histology results confirm the droplet size distribution in both control and high-fat diet tissues.

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