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Abstract #3471

Reproducibility of SMT-Based Microscopic Diffusion Anisotropy Imaging on a Clinical MRI System

Cara Louise Foley1, Enrico Kaden2, Kiran Seunarine1, Matt Hall1, David Carmichael1, Jonathan Clayden1, and Chris Clark1

1Developmental Imaging & Biophysics, University College London, London, United Kingdom, 2Centre of Medical Image Computing, University College London, London, United Kingdom

Diffusion Tensor Imaging (DTI) is a widely used neuroimaging technique, but it lacks specificity. Advanced diffusion models aim to yield greater biophysical information than DTI. This information is redundant if the parameters cannot be accurately reproduced across time-points. Multi-shell diffusion images were acquired on a single 3T scanner at two time-points for ten healthy adults. Mean parameter values from SMT-based microscopic diffusion anisotropy imaging and DTI were obtained in white matter, cortex and thalami. The advanced model performed similarly well to DTI in white matter, but was less consistent in the cortex and thalami, potentially due to its increased complexity.

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