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Abstract #3479

The impact of High-Q and High-K on complex fiber structures in the human brain

Iain Bruce1, Christopher Petty1, Hing-Chiu Chang2, Nan-Kuei Chen1,3, and Allen W Song1

1Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States, 2Department of Diagnostic Radiology, University of Hong Kong, 3Biomedical Engineering, University of Arizona, Tuscan, AZ, United States

In this diffusion MRI study, we investigated the impact of high angular resolution (high-Q) and high spatial resolution (high-K) on complex fiber structures. It was found that while high-Q was able to resolve crossing fibers within a given region, high-K provided additional spatial details of these crossing fibers in the same location. In addition, diffusion data from high-K improved characterization of high-curvature fibers, which cannot be adequately resolved with high-Q. It is thus concluded that high-K is preferred when both crossing and high-curvature fibers need to be resolved, as in human connectome analysis.

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