A common way to seed tractography is thresholding the Fractional Anisotropy (FA). This technique is problematic for aging diffusion MRI studies because the FA decreases dramatically in regions of White Matter Hyperintensities (WMH) and thus, the tractography can erroneously start or stop in these WMH regions. We show the importance for tractography pipelines to correct for WMH in their tracking masks. We show that the non-correction can lead to approximately 15% erroneous streamlines, which are false connections that can pollute the structural connectome and lead to misinterpretations.
This abstract and the presentation materials are available to members only; a login is required.