Histological necrosis is the current gold standard for response evaluation in Osteosarcoma treated with neoadjuvant chemotherapy (NAC). However it is applicable only after tumour resection on completion of NAC. Thus, a non-invasive early marker of NAC response is desirable. We performed NAC response evaluation using Intra-voxel Incoherent Motion (IVIM) Diffusion weighted MRI using tumour volume change and histogram analysis. Tumour volume change and histogram analysis revealed similar and clinically useful information in chemotherapy response to Osteosarcoma.