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Abstract #3525

Quantitative estimation of IVIM parameters and response evaluation after neoadjuvant chemotherapy in Osteosarcoma

Esha Baidya Kayal1, Devasenathipathy K2, Kedar Khare3, Raju Sharma2, Sameer Bakhshi4, and Amit Mehndiratta1,5

1Center for Biomedical Engineering, Indian Institute of Technology, New Delhi, India, 2Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India, 3Department of Physics, Indian Institute of Technology, New Delhi, India, 4Medical Oncology, Dr. B.R.Ambedkar Institute-Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India, 5Department of Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, India

Histological necrosis is the current gold standard for response evaluation in Osteosarcoma treated with neoadjuvant chemotherapy (NAC). However it is applicable only after tumour resection on completion of NAC. Thus, a non-invasive early marker of NAC response is desirable. We performed NAC response evaluation using Intra-voxel Incoherent Motion (IVIM) Diffusion weighted MRI using tumour volume change and histogram analysis. Tumour volume change and histogram analysis revealed similar and clinically useful information in chemotherapy response to Osteosarcoma.

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