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Abstract #3567

Detection of Acetaminophen-Induced Liver Damage using Contrast-Enhanced Dynamic MRI and T1 Maps

Christiane L Mallett1, Matthew Latourette1, Jeremy Hix1, Alexander Wolf1, and Erik M Shapiro1

1Radiology, Michigan State University, East Lansing, MI, United States

We are developing an MRI method to measure acetaminophen toxicity in the liver. We obtained dynamic T1 weighted images of the liver and T1 maps using the clinically approved contrast agent gadoxetate disodium (Eovist). After acetaminophen overdose, the uptake of contrast was decreased in the liver and increased in the kidney. T1 and variation in T1 were higher after acetaminophen. T1 was correlated with ALT, a serum measure of liver damage. This is a promising method for quantifying drug induced liver damage in vivo.

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