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Abstract #3584

Use of Gadofosveset-enhanced Lung MRI to Assess Ongoing Lung Injury in Fibrotic Interstitial Lung Disease.

Sydney B Montesi1, Rohan Rao1, Lloyd Liang1, Subba Digumarthy2, Amita Sharma2, Peter Caravan2, Andrew Tager1, and Ravi Seethamraju3

1Medicine, Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, United States, 2Radiology, Massachusetts General Hospital, Boston, MA, United States, 3Siemens Healthcare, Boston, MA

Vascular leak is a cardinal response to injury, and prior assessments of alveolar-capillary permeability suggest that vascular leak is present in the lungs of patients, and that its extent is associated with progression and mortality. We hypothesized that the degree of vascular leak present reflects the extent of ongoing lung injury, and that measuring lung vascular permeability consequently could provide a much-needed metric for assessing ILD disease activity and predicting disease progression. Using magnetic resonance imaging with the albumin-binding contrast agent gadofosveset, we were able to detect increased vascular permeability in the lung of patients with fibrotic ILD.

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