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Abstract #3587

Multi-parametric 11C-Methionine-PET/MRI for brain tumor imaging utilizing MR Fingerprinting.

Lale Umutlu1, Jasmin Jaeger1, Matthias Nittka2, Stephan Kannengiesser 2, Josef Pfeuffer 2, Gregor Koerzdoerfer 2, Rainer Kirsch2, Florian Meise2, Harald Quick3,4, Vikas Gulani5, Mark Griswold5, Ken Herrmann6, Marcel Gratz3,4, and Michael Forsting1

1Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3University Duisburg-Essen, Erwin L. Hahn Institute for MR Imaging, Essen, Germany, 4High Field and Hybrid MR Imaging, University Hospital Essen, Germany, 5Case Western Reserve University, Cleveland, OH, 6Department of Nuclear Medicine, University Hospital Essen, Essen, Germany

The successful implementation of integrated PET/MR systems has enabled a unique platform for simultaneous multi-parametric imaging comprising morphologic, functional and metabolic features of pathologic tissue. MR Fingerprinting has been recently presented as a robust and fast framework for simultaneous accurate quantification of multiple MR tissue properties. The results of our study, combining tissue characterization based on PET/MR imaging and MR Fingerprinting, indicate a correlation between tumor grading and changes in tissue features, demonstrating the high diagnostic potential of this novel approach for multi-parametric tissue characterization.

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