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Abstract #3603

Multiparametric tumor characterization using simultaneous 1H-MRI, [18F]FDG PET and hyperpolarized [1-13C]pyruvate MRSI

Christian Hundshammer1,2, Miriam Braeuer1, Müller Christoph3,4, Adam Espe Hansen5, Jorge Cabello1, Mathias Schillmaier6, Benedikt Feuerecker1, Stephan Duewel1,2,7, Schachoff Sylvia1, Birgit Blechert1, Michael Michalik1, Jan-Bernd Hövener3,4, Steffen J. Glaser2, Axel Haase7, Franz Schilling1, Andreas Kjaer5, Stephan Nekolla1, and Schwaiger Markus1

1Department of Nuclear Medicine, Klinkum rechts der Isar, Munich, Germany, 2Department of Chemistry, Technical University Munich, Munich, Germany, 3Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 4German Consortium for Translational Cancer Research (DKTK), Partnersite Freiburg, German Center for Cancer Research (DKFZ), Heidelberg, Germany, 5Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark, 6Department of Radiology, Klinikum rechts der Isar, Munich, Germany, 7Deparment of Medical Engineering, Technical University Munich, Munich, Germany

In order to understand complex mechanisms of the tumor biology, multimodal imaging approaches are useful. Here we present a workflow to characterize subcutaneous MAT-B-III tumors in rats on a clinical 3T PET/MR. Proton imaging was used for tumor localization and to characterize tumor cellularity by diffusion-weighted imaging. Glucose uptake and downstream glucose metabolism of pyruvate by lactate dehydrogenase (LDH) was addressed by [18F]FDG-PET and hyperpolarized [13C]pyruvate metabolic imaging. The [18F]FDG standard uptake values and the LDH activity were consistently and reproducibly higher compared to normal tissue.

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