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Abstract #3639

Investigating the relation between electrical conduction and tissue composition with proton and sodium MRI

Stefano Mandija1, Paul W de Bruin2, Andrew G Webb2, Peter R Luijten1, and Cornelis AT van den Berg1

1Center for Image Sciences, Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands, 2Radiology, Gorter Center for High-field MRI, LUMC Leiden, Leiden, Netherlands

The focus of the presented work is to understand the relation between electrical conductivity and tissue composition in terms of 23Na concentration and water fraction. This would be relevant to evaluate the potential value of electrical conductivity imaging as a new endogenous biomarker and the validity of accessing conductivity from water content. For this purpose, MR-EPT and waterEPT conductivity reconstructions are performed and compared to network analyzer measurements. To evaluate whether conductivity is directly related to the total sodium concentration in free water, 23Na images are acquired at 7T and conductivity reconstruction are then performed using the Stogryn’s model.

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