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Abstract #3648

Longitudinal Atlas Construction for Normative Human Brain Development and Aging over the Lifespan using Quantitative Susceptibility Mapping (QSM)

Yuyao Zhang1, Hongjiang Wei1, Naying He2, Christian Langkammer 3, Stefan Ropele 3, Fuhua Yan2, and Chunlei Liu1

1University of California, Berkeley, berkeley, CA, United States, 2Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, People's Republic of China, 3Department of Neurology, Medical University of Graz, Graz, Austria

QSM is able to provide high contrast for iron-rich deep-brain nucleus. This is attributed to the sensitivity of magnetic susceptibility to the spatial variations of cellular components that exhibit different magnetic susceptibility properties, especially for brain iron and myelin. Although there have been atlases proposed for certain age groups, a longitudinal statistical atlas construction from general healthy population based on QSM is still lacking. We constructed longitudinal QSM atlases over the whole lifespan (from 1 to 83 years-old). One common QSM atlas is built for every 10-years interval to demonstrate the unique age-specific morphology and appearance of human brains.

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