Iron overload can affect not only the central nervous system, but the liver, pancreas, myocardium, endocrine glands, and musculoskeletal structures. A reliable quantitative method to detect and measure high concentration iron in vivo would be of great clinical utility. Ultrashort echo time (UTE) sequences have echo times (TE) 100-1000 times shorter than clinical sequences, and may detect signal from high iron concentration. In this study, we aimed to evaluate the capability of UTE-QSM sequence in quantifying high iron concentration with an Iron phantom study and the results show that UTE-QSM techniques can quantify high iron concentration up to 22 mM or higher.
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