An interleaved multi-echo imaging sequence is proposed to improve off-resonance robustness for spectral-spatial excitation and echo-planar imaging of hyperpolarized [1-13C]pyruvate. A non-iterative pointwise k-space signal decomposition approach for removing pyruvate hydrate contamination from lactate images is presented. Performance of the sequence and reconstruction pipeline was evaluated using an ethylene glycol phantom and a catalyzing enzyme system. Minimal signal loss and successful removal of pyruvate hydrate contamination were demonstrated in vivo for realistic cases of off-resonance.
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