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Abstract #3708

Combined Hyperpolarized Pyruvate and Lactate as a Proxy for Hyperpolarized Urea to Measure Tissue Perfusion

Christopher M Walker1, Keith A Michel1, Rafal J Zielinski2, Waldemar Priebe2, Dawid Schellingerhout3, and James A Bankson1

1Department of Imaging Physics, UT MD Anderson Cancer Center, Houston, TX, United States, 2Department of Experimental Therapeutics, UT MD Anderson Cancer Center, Houston, TX, United States, 3Department of Diagnostic Radiology, UT MD Anderson Cancer Center, Houston, TX, United States

Hyperpolarized pyruvate can be used to noninvasively probe metabolism in vivo. However, quantitative measurement of metabolic processes is frequently complicated by tissue perfusion. Metabolic inert compounds such as hyperpolarized urea have been used to measure tissue perfusion. This work shows a strong correlation between hyperpolarized urea signal and the sum of hyperpolarized pyruvate and lactate signal, suggesting that the combination of pyruvate and lactate signals can be used to estimate tissue perfusion.

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