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Abstract #3751

Voxel-wise comparison of amide proton transfer (APT) weighted image and fluorodeoxyglucose (FDG)-PET in brain tumors with a PET/MR system

Koji Sagiyama1, Yuji Watanabe2, Ryotaro Kamei1, Sungtak Hong3, Jochen Keupp4, and Hiroshi Honda1

1Department of Clinical Radiology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, 2Department of Molecular Imaging and Diagnosis, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, 3Healthcare, Philips Electronics Japan, 4Philips Research

Amide proton transfer (APT) imaging has been reported to be useful for assessing malignancy or evaluating treatment efficacy. In this study, we evaluated the validity of APT signals in brain tumors by direct voxel-wise comparison with standardized uptake values (SUVs) from fluorodeoxyglucose positron emission tomography (FDG-PET) on a PET-magnetic resonance (PET/MR) system. APT imaging showed discrepancies with FDG-PET due to structural inhomogeneity, and the correlation between APT signals and SUVs was poor. The correlation was significantly improved after correcting for the apparent diffusion coefficient (ADC). APT/ADC could be a reliable metabolic marker with better correlation with SUVs.

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