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Abstract #3763

Characterization of the power dependency regimes of inhomogeneous Magnetization Transfer (ihMT)

Samira Mchinda1, Gopal Varma2, Valentin H Prevost1, Arnaud Le Troter1, Maxime Guye1,3, Jean Pelletier1,4, Jean-Philippe Ranjeva1, David C Alsop2, Guillaume Duhamel1, and Olivier M Girard1

1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 3Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle d'Imagerie Médicale, CEMEREM, Marseille, France, 4Aix Marseille Univ, APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France

Inhomogeneous magnetization transfer (ihMT) is a new MRI technique that shows promise for myelin imaging. A significant boost of the ihMT signal intensity is achievable when using a concentrated energy deposition scheme. Here we characterized the power dependency of ihMT for various energy deposition schemes (distributed vs. concentrated RF) and we identified distinct regimes with linear, sub-linear and saturated B1 dependency. This has a strong impact on the ihMT response to variable sequence configurations and on the most suitable conditions for different field strengths, e.g. to enhance sensitivity or provide immunity to B1+ inhomogeneities.

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