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Abstract #3787

Non-invasive 3T lymphangiography using 3D velocity-suppressed T2-weighted MRI

Rachelle Crescenzi1, Paula M.C. Donahue2,3, Allison O Scott1, Vaughn G Braxton1, Helen B Mahany1, Sarah K Lants1, and Manus J Donahue1,4,5,6

1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, 3Vanderbilt Dayani Center for Health and Wellness, Nashville, TN, United States, 4Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 5Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States, 6Physics and Astronomy, Vanderbilt University, Nashville, TN, United States

We demonstrate for the first time abilities to perform lymphangiography non-invasively using turbo-spin-echo 3.0T MRI pulse sequences. Contrast consistent with lateralizing disease was observed in patients with known secondary lymphedema from breast cancer treatment-related lymphedema, which also adjusted in an expected manner following manipulation of lymphatic stasis through manual lymphatic drainage therapy. These findings suggest that MRI may be well-suited to evaluate lymphatic functioning and lymphedema treatment response, and may have relevance for informing personalized lymphedema risk before surgery or following breast cancer therapies.

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