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Abstract #3803

Estimation of arterial blood T1 during hyperoxic gas-mixture breathing

Erin K Englund1, Zachary B Rodgers1, Hyunyeol Lee1, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Hyperoxia gas mixture breathing causes additional oxygen to be dissolved in blood plasma thereby shortening the T1 of arterial blood (T1a). Here, we propose a method estimate T1a during hyperoxia gas breathing by solving a perfusion quantification model for T1a given CBF measured during hyperoxia via phase contrast (PC) of the feeding arteries in the neck. The ratio between PC-based total CBF and ASL-based regional CBF was first determined at baseline, and then applied to normalize the expected ASL-based CBF during hyperoxia. T1a was estimated as 1.46±0.09 s during hyperoxia gas mixture breathing, in reasonable agreement with previous reports.

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