Abstract #3883

Validation of an Image Derived Input Function Method for PET/MR Brain Scans

Mohammad Mehdi Khalighi¹, Mathias Engström², Mark Lubberink³, and Greg Zaharchuk⁴

¹Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, ²Applied Science Lab, GE Healthcare, Uppsala, Sweden, ³Nuclear Medicine & PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden, ⁴Radiology Department, Stanford University, Palo Alto, CA, United States

Accurate measurement of the arterial input function (AIF) is essential in quantitative analysis of cerebral blood flow (CBF) using ¹⁵O-water PET imaging. The time-of-flight enabled SIGNA PET/MR scanner (GE Healthcare, Waukesha, WI, USA) provides high quality PET images, which can be used for non-invasive Image Derived Input Function (IDIF) estimation. AIF was measured using a proposed IDIF method on 4 patients and the results were compared with the gold standard, arterial blood sampling. The comparison shows excellent correspondence between IDIF and blood sampling, thus validating the IDIF method.

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