Abstract #3967

Comparison of R2* and B0 Field in 2D and 3D Ferumoxytol-Enhanced Chemical Shift-Encoded MRI of the Healthy Rhesus Placenta

Ante Zhu^1,2, Ann Shimakawa³, Sydney Nguyen⁴, Kevin M. Johnson^2,5, Ian M. Bird⁴, Ted Golos^4,6,7, Sean B. Fain^1,2,5, Dinesh M. Shah⁶, Oliver Wieben^2,5, Scott B. Reeder^1,2,5,8,9, and Diego Hernando^2,5

¹Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Global MR Applications and Workflow, GE Healthcare, Menlo Park, CA, United States, ⁴Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁶Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, United States, ⁷Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States, ⁸Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁹Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

A motion-robust 2D sequential chemical shift-encoded MRI (CSE-MRI) technique with a short temporal footprint for each slice is investigated for ferumoxytol-enhanced MRI of placental inflammation. In this study, the proposed 2D technique was compared with the reference 3D-CSE-MRI technique in healthy pregnant rhesus, which were anesthetized eliminating fetal motion. B0 field map boundary measurements, as well as R2* measurements in the placenta were compared across the two techniques to assess the accuracy of the 2D technique. High correlations between the measurements from 2D-CSE-MRI and 3D-CSE-MRI were demonstrated and thus provide promise for motion-robust imaging of human placental inflammation.

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