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Abstract #4059

Toward a standardized quantitative imaging protocol for multiple sclerosis: a multisite study of magnetization transfer and quantitative T1 imaging techniques

Ian Tagge1, Daniel Schwartz1, Katherine Powers1, Rohit Bakshi2, Peter Calabresi3, Todd Constable4, John Grinstead1,5, Roland Henry6, Govind Nair7, Jiwon Oh3,8, Li Pan9, Nico Papinutto6, Daniel Pelletier10, Daniel S Reich7, Nancy Sicotte10, Jack Simon1, William Stern6, and William Rooney11

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Brigham & Women's Hospital, Harvard Medical School, 3Johns Hopkins, 4Yale, 5Siemens Medical Solutions, Portland, OR, 6University of California San Francisco, 7National Institute of Neurological Disease and Stroke, National Institute of Health, 8University of Toronto, 9Siemens Healthcare, Baltimore, MD, 10University of Southern California, Keck School of Medicine, 11Oregon Health & Science University, Portland, OR, United States

The current lack of standardization in MRI protocols leads to increased variability, particularly in semi-quantitative techniques such as MTR, and makes comparisons between studies almost impossible. A single subject with clinically stable RRMS travelled to seven North American sites and underwent two distinct 3T MRI sessions following a standardized MTR and qT1 protocol at each site. Both MTR and qT1 mapping have been shown to have potential in elucidating tissue characteristics and underlying pathology. This work demonstrated that use of carefully standardized protocols produces consistent quantitative and semi-quantitative measurements across sites in MS brain tissue in-vivo.

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