The current study investigated the effect of sonic hedgehog agonist (SAG) treatment in post-stroke recovery. SAG- and vehicle-treated mice were evaluated with MRI at day 2 and day 30 after middle cerebral artery occlusion (MCAO) surgery. Our results show that SAG treatment showed significantly increased cerebral perfusion in the ischemic penumbra at day 30, suggesting enhanced angiogenesis. In addition, SAG-treated mice also exhibited decreased T2, suggesting reduced neuronal damage. These results suggest that the sonic hedgehog signaling pathway can be a potential therapeutic target for stroke treatment.