Myelin injury and repair are associated with many neurological diseases including multiple sclerosis. We evaluated the utility of NODDI and MRI texture analysis for assessing myelin integrity using a mouse model of de- and re-myelination. Following lesion induction in mouse spinal cord, 9.4T MRI was conduced during demyelination (day 7) and ongoing remyelination (days 14, 28, and 35). With histological verification, both texture heterogeneity and neurite orientation dispersion (ODI) increased when demyelination occurs. But the latter showed persistent recovery with remyelination, similar to lesion size. These findings suggest the utility of ODI and texture heterogeneity as measures of myelin integrity.