Abstract #4086

Mapping and modulation of Down Syndrome specific functional network in Dp(16)1yey mouse model

Laura-Adela Harsan^1,2,3, Meltem Karatas¹, Thu Lan NGUYEN⁴, Anna Mechling³, Tanzil Arefin ³, Thomas Bienert³, Hsu-Lei Lee³, Dominik von Elverfeldt³, and Yann Herault⁴

¹Engineering science, computer science and imaging laboratory (ICube), University of Strasbourg-CNRS France, Strasbourg, France, ²Biophysics and Nuclear Medicine, Faculty of Medicine and University Hospital, Strasbourg, Strasbourg, France, ³Medical Physics, AMIR, University Hospital, Freiburg, Freiburg, GA, Germany, ⁴Translational medicine and neurogenetics, Institute of Genetics and Molecular Imaging, University of Strasbourg

Resting state functional MRI (rsfMRI) is currently the only non-invasive approach capable of giving insight into the large-scale cerebral networks architecture and its dynamic changes in pathology or following therapeutic interventions. With the aim of deciphering specific network signatures underlying memory and cognitive impairments in Down Syndrome pathology, we performed rsfMRI and network analysis in the Dp(16)1yey mouse model. We found perturbed synchrony of BOLD-signal in the hippocampal network of Dp(16)1yey mice. We further modulated this memory specific cerebral circuitry via therapeutic treatment with a DYRK1A kinase inhibitor, aimed at rescuing the memory and cognitive dysfunctions characterizing this mouse model.

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