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Abstract #4098

Assessment of subcortical white matter myelination progression based on T2WI visual evaluation during the age of 6-48 months: a DTI-based validation study

Congcong Liu1, Zhijie Jian2, Xianjun Li2, Chao Jin3, Miaomiao Wang3, Heng Liu3, and Jian Yang3

1Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an,China, People's Republic of China, 2Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P.R. China, 3Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, P.R. China, People's Republic of China

Assessment of WM myelination is important to diagnose WM disorders in infants and children. We retrospectively evaluated 109 subjects (age of 6-48 months) using modified Cecilia Parazzini’s scoring method based on T2WI visual evaluation. A significantly positive correlation was found between age and total scores of WM myelination with non-linear correlation coefficient of 0.948 (p<0.01). TBSS results demonstrated WM myelination progressed rapidly during age of 6-20 months and relatively stable during age of 21-48 months. The modified scoring method was more applicable to assess the WM myelination in infant with age of 6-20 months.

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