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Abstract #4144

Co-activation Pattern Analysis in Parkinson’s Disease

Xiaowei Zhuang (co-first)1, Ryan R Walsh (co-first)1, Zhengshi Yang1, Virendra Mishra1, Karthik Sreenivasan1, and Dietmar Cordes1,2

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States

In this study, we explored the dynamics of Parkinson’s disease (PD) brain network function utilizing the co-activation pattern (CAP) analysis emphasizing sensorimotor network (SM) function during resting-state. We modified the routine to calculate group dominant CAPs (d-CAPs) and proposed a novel way to obtain within-subject CAP switching-rate. Reduced dynamics of the SM network in PD was demonstrated by both decreased number of d-CAPs and decreased switching-rate, which corroborates electrophysiologic data.

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