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Abstract #4162

Susceptibility-related phase contrast associated with the alterations of myelo-architecture in adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia

Hansol Lee1, Minkyeong Kim2, HyungJoon Cho1, Se Young Chun3, Gi Yeong Huh4, Eun-Joo Kim5, and Jae-Hyeok Lee6

1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 2Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of, 3Department of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 4Department of Forensic Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of, 5Department of Neurology, Pusan National University Hospital, Busan, Korea, Republic of, 6Department of Neurology, Pusan National University Yangsan Hospital

To investigate the origin of susceptibility-weighted imaging (SWI) contrast in frontal white matters of adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia (ALSP), we performed a combined post-mortem magnetic resonance imaging (MRI) and histological study of ALSP pathology. The myelin architectural changes, marked central myelin loss with preserved U-fibers beneath cortical gray matter, mainly contributed to the susceptibility contrast.

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