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Abstract #4174

True progression versus radiation necrosis in glioma: a comparative study of arterial spin labelling and dynamic susceptibility contrast imaging

Qian Xu1, Kai Xu1, Qi Liu1, Hong Ma1, Jiangfen Wu2, and Jianxun Qu2

1Department of radiology, Affiliation hospital of Xuzhou Medical University Department of Radiology, Xuzhou, People's Republic of China, 2GE Healthcare, Shanghai, People's Republic of China

Differentiation of treatment-related radiation necrosis from recurrent neoplasm is often difficult and dynamic susceptibility contrast perfusion MR imaging (DSC-MRI) is reported to be a surrogate marker for distinguishing them. However, DSC technique is invasive and has its disadvantage. Three dimensional pseudo-continuous ASL (3D-pcASL) can provide noninvasive absolute cerebral blood flow (CBF) measurement with insensitivity to permeability, and it is especially necessary for the evaluation of the postoperative gliomas patients where the blood-brain barrier (BBB) is completely broken with much more leakage effects. This study aimed to differentiate true progression from radiation necrosis of gliomas by using 3D-pcASL and DSC-MRI.

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