Neuroimaging plays critical diagnostic and prognostic role in the management of brain tumors. However, there can be a significant overlap in the imaging features between neoplastic and various non-neoplastic pathological processes in the brain. The knowledge of key differentiating features of such non-neoplastic entities is essential for a radiologist to facilitate accurate and timely diagnosis. Additionally, in such settings, judicious use of advanced imaging techniques such as perfusion imaging and spectroscopy can help the radiologist as problem-solving tools. In this exhibit, we review the conventional and advanced imaging features of different disease processes that are encountered in day-to-day clinical practice and can mimic brain neoplasms on imaging.