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Abstract #4208

Individual metabolic differences in murine nucleus accumbens (NAc) measured by 1H-MRS at 14.1 Tesla is associated with trait-anxiety levels

Antoine Cherix1, Thomas Larrieu2, Arantxa Duque Moreno3, Hongxia Lei4, Santiago Moléon3, Carmen Sandi2, and Rolf Gruetter1,5,6

1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Laboratory of Behavioral Genetics (LGC), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Department of Psychobiology, University of Valencia, Valencia, Spain, 4Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 5Department of Radiology, University of Geneva, Geneva, Switzerland, 6Department of Radiology, University of Lausanne, Lausanne, Switzerland

1H-MRS was used to study metabolic changes associated with basal anxiety levels in nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) of naive mice. Results indicate some neuroenergetic differences specific to the NAc, which supports the idea that this structure plays a critical role in the etiology of anxiety.

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