A two-region approach to assess brain iron changes as a function of age in basal ganglia, midbrain and dentate nuclei of healthy subjects using quantitative susceptibility mapping
Kiarash Ghassaban1, Sean K Sethi1, Shuang Xia2, and E. Mark Haacke1,3
1Magnetic Resonance Innovations Inc., Detroit, MI, United States, 2Department of Radiology, Tianjin First Central Hospital, Tianjin, People's Republic of China, 3Department of Radiology, Wayne State University, Detroit, MI, United States
In this work, 81 healthy subjects were recruited to assess iron deposition as a function of age in eight major brain nuclei using quantitative susceptibility mapping. By thresholding out high iron content region for each structure, seven basal ganglia and midbrain structures were evaluated locally and compared with the literature. Global (the entire structure) and regional (high iron content) susceptibility changes versus age were also analyzed for the dentate nucleus. In addition to the global analysis being consistent with the literature, regional analysis showed more sensitivity and precision as well as the left hemisphere dominance in terms of iron deposition.
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