Numerous studies have revealed that DTI-derived metrics are sensitive to the microstructural changes of the aging white matter tracts. However, microstructural changes associated with non-Gaussian water diffusion cannot be quantified by DTI-derived metrics, but uniquely quantified by DKI-derived metrics. Little is known on the progressive white matter microstructural changes measured by DKI-derived metric during aging. In this study, we found that the measurements of DKI-derived mean kurtosis (MK) decrease heterogeneously across white matter tracts, characterized with significant MK decreases in limbic tracts including fornix and cingulum and insignificant MK decreases in the association tracts.
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