Abstract #4278

Both Rostral and Dorsal Anterior Cingulate Cortices Exhibit Age-related Metabolic Changes

Pui Wai Chiu^1,2, Hui Zhang¹, Savio Wai Ho Wong³, Tianyin Liu⁴, Gloria Hoi Yan Wong⁵, Queenie Chan⁶, and Henry Ka Fung Mak^1,2,7

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Special Education and Counselling, The Education University of Hong Kong, Hong Kong, Hong Kong, ⁴Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, ⁶Philips Healthcare, Hong Kong, Hong Kong, Hong Kong, ⁷Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong

Rostral ACC displays a characteristic task-induced deactivation, while dorsal ACC displays positive BOLD responses in cognitive tasks. Nevertheless, the effect of age on the rostral ACC and dorsal ACC has never been investigated within the same cohort. In this study, quantitative proton magnetic resonance spectroscopy was used to investigate the metabolic changes in the rostral ACC and dorsal ACC in a local Chinese cohort at 3.0T. Both rostral ACC and dorsal ACC showed age-related metabolic changes. Rostral ACC may reveal greater degree of compensation compared to dorsal ACC.

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