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Abstract #4356

Simultaneous imaging of tumor size with contrast-enhanced MRI and response to therapy with extracellular pH readout from BIRDS

Jyotsna Upendra Rao1,2, John Walsh3, Maxime Parent2, Yuegao Huang2, Meser Ali4, Daniel Coman2, and Fahmeed Hyder2,3

1Cardiff University School of Medicine, Cardiff, United Kingdom, 2Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States, 3Biomedical Engineering, Yale University, New Haven, CT, United States, 4Neurology, Henry Ford Hospital, Detroit, MI, United States

Acidic extracellular pH (pHe) of gliomas promotes tumor growth and builds resistance to therapy. Thus, to monitor therapeutic response, we used Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), to generate pHe maps of rat brains bearing U251 tumors. Upon TmDOTP5- infusion, MRI identified tumor boundary and BIRDS imaged the intratumoral and peritumoral pHe gradient (DpHe). Two weeks post implantation of U251 glioma cells, animals were either treated with temozolomide (40 mg/kg) or were left untreated. The results of both terminal and longitudinal studies suggest that temozolomide therapy hinders tumor growth and normalizes intratumoral pHe.

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